CurcuZIF

(Curcumin-ZIF-8 Nanocarrier for Early Photodynamic Therapy of Ovarian Cancer)

Ovarian cancer is one of the most lethal gynecologic malignancies due to its asymptomatic progression and late-stage diagnosis. Early detection and targeted therapy are critical for improving survival rates. Photodynamic therapy (PDT), a non-invasive and site-specific technique, utilizes photosensitizers like curcumin that, upon light activation, generate reactive oxygen species (ROS) to destroy cancerous cells.

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Mechanism of Action

Curcumin absorbs light (typically 400–500 nm)
Excited-state curcumin transfers energy to surrounding oxygen molecules
Generates singlet oxygen (¹O₂) and free radicals
Causes oxidative damage to tumor cell membranes, proteins, and DNA

Challenge Addressed
Ovarian cancer is frequently detected only in advanced stages.
CurcuZIF-PDT offers a dual function:

Targeted delivery and controlled release of curcumin to the tumor site
Light-triggered ROS generation to selectively kill cancer cells at an early stage

CurcuZIF

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Dr. Farah Farzaneh

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