Professor of Periodontics
Why Zeolite?
Zeolite, particularly ZSM-5, is a crystalline microporous aluminosilicate known for its high surface area, tunable Si/Al ratio, ion exchange capability, and high biocompatibility. Its incorporation into bone scaffolds offers dual benefits: mechanical reinforcement and drug delivery potential. Gelatin, a natural polymer, complements this system by enhancing cell adhesion and biodegradability.
ZeoGraft Composition and Properties:
Scaffold Matrix: β-TCP / ZSM-5 Zeolite (Si/Al = 371) / Gelatin
Drug Loaded: Clindamycin (to prevent post-operative infection)
Key Features:
• Highly porous structure suitable for cell migration and angiogenesis
• Reinforced mechanical strength from ZSM-5 integration
• Controlled local drug release through Zeolite’s high adsorptive capacity
• Biocompatible and osteoconductive environment provided by gelatin
In Vivo Evaluation
Animal Model: 15 Male New Zealand White Rabbits (2.5–3 kg)
Time Points: 4, 8, and 12 weeks post-implantation
Outcome:
• Progressive scaffold degradation
• Enhanced new bone formation
• No signs of inflammation or adverse tissue reaction
• Clindamycin effectively reduced infection risk, supporting faster regeneration
Conclusion
ZeoGraft combines the mechanical integrity of β-TCP, the biofunctionality of gelatin, and the intelligent release and structural benefits of ZSM-5 zeolite. This multifunctional scaffold represents a promising approach for bone regeneration, especially in infected or large defects where both structural support and drug delivery are crucial.
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