Graphical Abstract

Project Overview

Capillary Membrane Oxygenators (CMOs) require accurate and repeatable in vitro testing to validate their performance. However, using natural blood for these tests introduces significant complexity, high cost, and logistical challenges related to supply and stability. This project established a novel, non-blood-based method by developing and simulating the use of a modified sulfite solution as a chemically reliable and stable fluid substitute for testing CMO performance. The objective was to create a simple, repeatable system to benchmark oxygenator efficiency and simplify the development of future devices.

Major Outcomes

• Stable Blood Substitute: Successfully developed a modified sulfite solution as a safe, stable, and cost-effective alternative to natural blood for in vitro testing.
• Kinetic Model Validation: Established a simulation model to accurately describe the complex chemical kinetics of oxygen transfer and consumption within the sulfite solution.
• Performance Equivalence: Validated the model by demonstrating that the resulting oxygen concentration profiles and transfer rates closely mimic performance observed using human blood.
• Reliable Benchmarking Tool: Provided a reliable and simple method for researchers and manufacturers to benchmark and characterize the oxygen transfer capacity of Capillary Membrane Oxygenators.

The schematic diagram of the experiment circuit of the modified sulfite solution.

Paper Source

To access the paper, please click here.