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DexaMN

(Microneedle-based dexamethasone delivery system for knee osteoarthritis)
Knee osteoarthritis (OA) is a degenerative joint disorder affecting millions worldwide, characterized by chronic inflammation, joint stiffness, and cartilage degradation. Dexamethasone, a potent corticosteroid, is commonly used to alleviate inflammation in OA. However, conventional intra-articular injections are painful, require clinical expertise, and pose risks such as infection and bleeding.

Contact

Dr. Ali Poorkhalil

Assist. Professor of Biomedical Engineering

ali.poorkhalil@invitrovo.com

DexaMN-Knee is a painless, minimally invasive, and self-administered microneedle (MN) patch engineered for targeted and sustained delivery of dexamethasone to the knee joint.

Microneedle Specifications:

    • Auxetic MN array (needles height ≈ 775.5 µm) (See Figure 1)
    • Designed for maximum mechanical interlocking with knee tissue and enhanced drug retention
    • Optimized geometry minimizes displacement due to knee motion
Figure 1

Fabrication Method

    • Spin Coating of drug-polymer matrix into auxetic molds
    • Drying under controlled humidity
Figure 2

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