Myocardial infarction, leads to irreversible loss of cardiomyocytes and formation of scar tissue that disrupts the heart’s electrical conductivity and contractility. Traditional therapies only manage symptoms but fail to restore native tissue architecture and function.
Tissue engineering approaches using electrically conductive hydrogels offer a promising solution by providing both structural support and electrical signaling to reestablish synchronized myocardial contraction. This study presents MRGel, an injectable hydrogel composed of gelatin, alginate, and gold nanoparticles (AuNPs), engineered to mimic the native cardiac microenvironment and support the growth and function of mouse embryonic cardiac cells (mECCs).
You can access the paper by clicking the link: DOI.org/10.1002/mabi.202400301
