Professor of Cardiac Surgery
This study presents ElectroHeal, an injectable hydrogel composed of gelatin, alginate, and gold nanoparticles (AuNPs)—engineered to mimic the native cardiac microenvironment and support the growth and function of mouse embryonic cardiac cells (mECCs).
ElectroHeal Composition and Characteristics
Scaffold: Gelatin / Alginate / Gold Nanoparticles (AuNPs)
Drug/Growth Factor: None
Cells: Mouse Embryonic Cardiac Cells (mECCs)
Key Features:
• Injectable formulation for minimally invasive delivery
• Electrically conductive due to uniform dispersion of AuNPs
• Promotes electrical coupling between cardiac cells
• Excellent biocompatibility and cell adhesion
• Tailored gelation time and mechanical integrity suitable for cardiac tissue
In Vivo Evaluation
Animal Model:
Rat model of surgically induced MI Procedure:
Outcome:
• Improved electrical conductivity and tissue integration
• Enhanced mECC survival and alignment
• Reduction in fibrotic area and improvement in left ventricular function
• No significant inflammatory response observed
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