Graphical Abstract

Project Overview

This research introduces a comprehensive theoretical model designed to calculate the complex geometric data and configuration properties of Hollow-Fiber Membrane Oxygenators (HFMOs). The goal was to establish a systematic method for evaluating and optimizing the design specifications of these critical medical devices, focusing on the micro-porous membranes. The model enables a deep understanding of how physical design parameters, such as fiber pitch and winding patterns, directly influence the operational efficiency of the oxygenator.

The study applied the model to demonstrate how adjusting fiber bundle geometry can significantly enhance mass transfer and reduce resistance. By quantifying the relationship between design features and performance characteristics (like oxygen-transfer rate and blood pressure drop), the model provides a powerful tool for rationalizing and improving future HFMO designs.

Major Outcomes

• Design Optimization Model: Developed an extensive theoretical model for calculating and optimizing the geometric and configuration properties of Hollow-Fiber Membrane Oxygenators (HFMOs).
• Efficiency Factors Proposed: Introduced three new quantitative “efficiency factors” to scientifically evaluate and compare the design specifications of an HFMO with its performance characteristics.
• Guidance for Geometry: Provided specific, actionable recommendations on how to regulate the transverse and longitudinal pitches of fiber bundles to increase the number of windings and decrease the rand width.
• Performance Enhancement: Demonstrated that the proposed geometric modifications significantly improve module design, leading to a substantial increase in HFMO efficiency.
• Comparative Analysis: Used the calculated efficiency factors to compare the design effectiveness of various commercial oxygenators, identifying the Quadrox® as having a highly efficient design relative to its performance

Comparison of the examined HFMOs on the basis of their efficacy factors for a blood flow rate of 5 L/min

Paper Source

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