Diabetic foot ulcers (DFUs) are one of the most challenging complications of diabetes, characterized by chronic hypoxia, poor angiogenesis, and impaired wound healing. Conventional treatments often fall short in reversing the hypoxic microenvironment. A novel strategy involves utilizing oxygen-producing biomaterials to locally and sustainably release oxygen, thereby accelerating tissue regeneration. This study introduces OxyGel, an injectable hydrogel composed of gelatin, alginate, and microalgae (MA), engineered to release oxygen at the wound site and support diabetic foot ulcer (DFU) regeneration without the need for exogenous drugs or cells.