TXA-GelBrain

(Injectable Gelatin/Alginate Hydrogel for Hemostasis in Brain Surgery)
Arterial hemorrhage is a major complication during brain surgeries, especially in elderly patients with fragile vasculature. Rapid and localized hemostasis is critical to prevent severe neurological damage. Tranexamic acid (TXA) is an antifibrinolytic agent effective in stabilizing blood clots, but systemic administration poses risks like seizures and thrombosis.

Contact

Dr. Amin Jahanbakhshi

Associate Professor of Neurosurgery

Amin.Jahanbakhshi@invitrovo.com

System Design:
TXA-GelBrain is an injectable, biocompatible hydrogel engineered for localized delivery of TXA directly at the surgical site in brain tissue.

Figure 1
  • Hydrogel Matrix:
    • Gelatin/Alginate blend ensures injectability, biodegradability, and tissue compatibility
    • Crosslinked to tune mechanical strength and degradation kinetics
    • Modified to maintain TXA bioactivity while providing localized retention
  • Mechanical & Degradation Properties:
    • Tailored to match soft brain tissue mechanics, minimizing local pressure or damage
    • Controlled degradation allows sufficient time for clot stabilization while avoiding long-term residues
    • Rheological and compressive tests confirm optimal stiffness and resilience