Achieving precise control of liposome size while maintaining consistency and high uniformity is of paramount importance for improving the efficacy of nanoparticle-based therapies and minimizing potential side effects. Although microfluidic technologies are widely used for reliable nanoparticle synthesis, they face challenges in meeting critical homogeneity requirements, mainly due to imperfect mixing efficiency. Furthermore, channel clogging during continuous operation presents a significant obstacle in terms of quality control, as it progressively impedes the mixing behavior necessary for consistent liposome production for therapeutic delivery and complicates the scaling-up process. In this study the aim is to use 3D printed microfluidic chips to synthesize liposomes for drug delivery applications.
